Share Your Story

If you have been treated with Acthar for nephrotic syndrome and are willing to share your experience, please contact us and let us know your story.

Learn More »

Acthar Patient FAQs

Find answers to common patient questions.

Learn More »

Understanding Nephrotic Syndrome

Information on symptoms, diagnosis, resources, and more.

Learn More »

Nephrotic Syndrome & Diet

For patients with nephrotic syndrome, a well-planned diet can replace lost protein and ensure adequate calories to meet metabolic needs. Dietary modification also can help to control hypertension, edema, and elevated plasma cholesterol and slow the progression of renal disease.

High-protein diets are not recommended in patients with nephrotic syndrome because they may lead to further damage of the kidneys and result in progression of renal insufficiency. Protein loss in nephrotic syndrome is due to increased breakdown of proteins rather than decreased protein synthesis. As a result, low-protein diets, which decrease protein breakdown, may be more beneficial.

In patients with nephrotic syndrome, sodium intake may need to be limited to control edema and high blood pressure. Intake of foods with a high salt content and use of table salt should be limited.

Sodium also limits the ability of the kidneys to remove phosphorous from the blood. High phosphorous levels in the blood can weaken bones, making them easier to break. Intake of dietary sources of phosphorous (for example, dairy products, nuts, and beans) should be limited in patients with nephrotic syndrome.

A diet low in saturated fat and cholesterol is recommended for patients with nephrotic syndrome. This diet, combined with loss of excess body weight, is recommended to reduce the risk of cardiovascular disease. If necessary, drugs for lowering cholesterol can be used to supplement diet to reach cholesterol goals.

Caloric intake in the diet should be adequate to achieve and maintain ideal body weight and maintain protein stores. In patients with nephrotic syndrome, fewer calories should come from protein and more from other food sources, principally sugars and vegetable fats.

Questcor

Uses

H.P. Acthar^® Gel (repository corticotropin injection) is an adrenocorticotropic hormone (ACTH) analogue used for:

Monotherapy treatment of infantile spasms (IS) in infants and children under 2 years of age.
The treatment of exacerbations of multiple sclerosis in adults.
For inducing a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopathic type or that due to lupus erythematosus.
The following: rheumatic disorders; collagen diseases; dermatologic diseases; allergic states; ophthalmic diseases and respiratory diseases.

Important Safety Information

Patients, parents, and caregivers should be aware of the important information about H.P. Acthar^® Gel.

Acthar should never be given intravenously (into a vein). Acthar should not be used in patients with a skin condition called scleroderma, bone density loss (osteoporosis), infection throughout the body, eye infection called ocular herpes simplex, recent surgery, history of or a current stomach ulcer, heart problems, high blood pressure, or allergy to pig-derived proteins. Tell your doctor about any health problems or medicines.

Acthar may cause side effects similar to side effects that happen due to treatment with steroid medicines. Not all of these side effects have occurred with Acthar but they may occur. Acthar is a medicine that affects a patient’s immune system, and therefore patients may be more likely to get new infections, or inactive infections may become active. Acthar has effects on the adrenal gland. When a patient is taking Acthar, their adrenal gland may produce too much of a hormone called cortisol. This can cause symptoms of Cushing’s syndrome (upper body fat, rounded face, thin skin), which is more common in patients who take this medicine for a long time. When a patient stops taking Acthar after a long time, the body may not produce enough cortisol on its own (adrenal insufficiency). The doctor may prescribe a steroid medicine to protect the body until the adrenal gland recovers. Do not stop administering Acthar without talking to your doctor first. Blood pressure should be checked during treatment, and your doctor may instruct you to make some dietary changes. Patients should not receive certain vaccines during treatment with Acthar. Talk to your doctor about which vaccines are safe for use. Acthar may hide (or mask) symptoms of other conditions or diseases and it may be more difficult for your doctor to diagnose other conditions or diseases in you or your child during treatment. The person receiving Acthar has an increased risk for bleeding from the stomach or having a stomach ulcer. Inform your doctor about any pain in the stomach area, bloody vomit, or bloody or black stools. While on Acthar changes in mood and behavior such as irritability, depression, or trouble sleeping, may occur.

Other side effects are possible. Acthar may make certain other medical conditions worse, such as diabetes (may increase blood sugar); cause eye problems, such as cataracts, increased pressure in the eye (glaucoma), and possible damage to the optic nerve; and cause allergic reactions to Acthar (seen as skin rash, swelling of the face, tongue, lips, or throat, and trouble breathing). Acthar may affect growth and physical development after long term use. Long term use of Acthar may cause an increase in the size of the heart, but this condition usually goes away after Acthar is stopped.

The most common side effects of Acthar in infants include: infections, increased blood pressure, irritability and changes in behavior, changes in appetite and weight, diarrhea, and vomiting. Other adverse reactions reported in adults and children over 2 years of age included: abdominal bloating, anxiety, asthma, chest discomfort, congestive heart failure, dizziness, shortness of breath, redness of the face, fluid retention, flushing, headache, injection site pain, tiredness, muscle weakness, nervousness, rapid heart rate and lack of energy. Tell your doctor if there is any side effect that bothers you or your child or that does not go away. These are not all of the possible side effects of Acthar. For more information, ask your doctor, nurse, or pharmacist or call 1-800-465-9217. You may report side effects to the FDA at 1-800-FDA-1088.

For a full list of warnings, precautions, and adverse events related to Acthar, please refer to the full Prescribing Information and discuss this information with your healthcare provider.

H.P. Acthar^® Gel and Questcor^® are registered trademarks of Questcor Pharmaceuticals, Inc.