Exploring Acthar mechanism of action: Effects beyond steroidogenesis
Acthar is reported to bind to all 5 melanocortin receptors, producing both direct and indirect effects
Acthar is believed to have direct immunomodulatory and anti-inflammatory properties
- Acthar also has indirect effects through stimulation of cortisol release
- Steroids have been demonstrated not to bind to any of the 5 known melanocortin receptors
Melanocortin receptors are expressed on a wide variety of tissues and cells with a number of potential biologic functions
Further investigation into the pharmacology is being conducted
While the exact mechanism of action of Acthar is unknown, further investigation is being conducted.
This information is based on nonclinical data and the relationship to clinical benefit is unknown.